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A Case Study of Using Common Low Moisture Fillers in the Roller Compacted Tablets

OBJECTIVE
The aim of this study was to compare the benefit of using common low moisture grade pharmaceutical excipients: Mannitol, NF (Grades: Pearlitol® 300 DC, Pearlitol® 160c) (Roquette) and/or Microcrystalline Cellulose, NF (Grades: Avicel® PH-­‐200 LM, Avicel ® PH 112) (FMC Corp.) as fillers in a tablet formulation to limit the moisture uptake by a model hygroscopic drug manufactured with a roller compaction process.

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